Venlafaxine in dogs and cats
Common info
Venlafaxine (or Aphex, as a trade name). It’s an antidepressant that will increase the concentration of neurotransmitters or norepinephrine in the body and brain. But, Venlafaxine is toxic to dogs and cats, especially cats, and they like to eat Venlafaxine, causing elevated heart rate, dilatated pupils, diarrhea, painting, shivering (tremors), and vomiting.
History
Wyeth first introduced Venlafaxine in Wainafine in 1993. Now, the drugs sold by Pfizer.
Description
Venlafaxine is a remedy for depression that helps to inhibit the absorption of norepinephrine and Serotonin in the brain. Overdose may lead to a disease called serotonin syndrome.
Symptoms
- Diarrhea
- Dilated pupils
- Elevated heart rate
- Painting
- Shivering
- Tremors
- Seizures
- Twitching
- Vomiting
- Abdominal pain
- Confusion
- Drooling
- Elevated temperature
- High temperature
- Lethargy
When the dogs and cats receive Venlafaxine, it will cause abdominal pain, depression, confusion, dilated pupils, diarrhea, drooling, elevated temperature, lethargy, elevated heart rate, panting, seizures, twitching, shivering, tremors and vomiting.
Treatment and Prevention
If the dogs and cats have received an overdose of Venlafaxine, they should take to a veterinarian immediately, and Venlafaxine should keep away from dogs and cats.
- Wikipedia | Information of Venlafaxine
- Verywell Mind | Symptoms to Watch for When a Dog Eats an Antidepressant
- Wag! | Effexor Poisoning in Dogs
- Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, Wong DT (December 2001). "Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors" (PDF). Neuropsychopharmacology. 25 (6): 871–80. doi:10.1016/S0893- 133X(01)00298-6. PMID 11750180.
- Epstein, M.E. 2014. Managing Chronic Pain in Dogs & Cats. Today’s Veterinary Practice.
- Fontenot, M.B., M.W. Musso, R.M. McFatter and G.M. Anderson. 2009. Dose-Finding Study of Fluoxetine and Venlafaxine for the Treatment of SelfInjurious and Stereotypic Behavior in Rhesus Macaques (Macaca mulatta). Journal of the American Association for Laboratory Animal Science. 48(2): 176-184.
- KuKanich, B. 2013. Outpatient Oral Analgesics in Dogs and Cats Beyond Nonsteroidal Antiinflammatory Drugs: An Evidence-based Approach. Vet Clin Small Anim. 43: 1109–1125.
- Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. pp. 254, 255. ISBN 978-0-85711-084-8.
- Muth EA, Haskins JT, Moyer JA, Husbands GE, Nielsen ST, Sigg EB (December 1986). "Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative". Biochemical Pharmacology. 35 (24): 4493–7. doi:10.1016/0006-2952(86)90769-0. PMID 3790168.
- Rossi S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
- Saglama, E., I.T. Uzbay, H. Kayir, T. Celik and M. Beyazyurek. 2004. Effects of venlafaxine on ethanol withdrawal syndrome in rats. Fundamental & Clinical Pharmacology. 18: 693–698.
- Yardley JP, Husbands GE, Stack G, Butch J, Bicksler J, Moyer JA, Muth EA, Andree T, Fletcher H, James MN (October 1990). "2-Phenyl-2-(1-hydroxycycloalkyl) ethylamine derivatives: synthesis and antidepressant activity". Journal of Medicinal Chemistry. 33(10): 2899–905. doi:10.1021/jm00172a035. PMID 1976813.
