Glycogen storage disease (glycogenosis) in cat

Common info

Glycogen storage disease or glycogenosis is caused by genetic deficiency. It’s the abnormality in the enzyme. glycogen storage disease is an accumulation of. glycogen(GSD, glycogenosis, and dextrinosis). The metabolism is abnormal because of the lack of the enzyme which usually in the muscles and liver cells and it affects glycogen synthesis.


It was reported in 1929 by a German doctor, Edgar Otto Conrad von Gierke and in 1952 by Cori and Cori which could identify the cause of the disease which is the enzyme deficiency called glucose 6-phosphatase, derived from glycogen metabolism deficiency. Glycogen Storage Disease is derived from the genetic abnormalities in dogs caused by Enzyme glucose-6-phosphatase which can produce glucose less than usual and causes the decrease of glucose burning process efficiency in the blood and affect the liver which can cause death.


Glycogen storage disease or glycogenosis in cats is caused by cross-breeding of Norwegian forest cats.


Common symptoms in cats

  • Fever
  • Muscles are shaking
  • Weakness
  • Paralysis
  • Low glucose in the blood
  • Growth disorder

Treatment and Prevention

The basic treatment Glycogen storage is injecting more glucose in the pet’s blood through the vein. The death rate of the disease is high.

  1. Wag! | Glycogen Storage Disease in Cats
  2. PET MD | Glycogen Storage Disease in Cats
  3. Albert Grinshpun, Reba Condiotti, Simon N Waddington, Michael Peer, Eli Zeig, Sima Peretz, Alina Simerzin, Janice Chou, Chi-Jiunn Pann, Hilla Giladi and Eithan Galun. 2010. Neonatal Gene Therapy of Glycogen Storage Disease Type Ia Using a Feline Immunodeficiency Virus–based Vector. The American Society of Gene & Cell Therapy. vol. 18 no. 9 : 1592–1598.
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